PROFIL PRACOWNIKA: Karolina Kowalczyk
dr Karolina Kowalczyk
SCIENTIFIC AND SOCIAL MEDIA PROFILES
POSITION DESCRIPTION
Performing/Recording NMR SpectraTechnical Maintenance of NMR Spectrometers (Avance III and AvanceNeo Spectrometer equipped with a Prodigy cryoprobe), including refilling cryogenic liquids (liquid nitrogen and liquid helium)Administrative Support Related to Conducted AnalysesConducting Scientific Research
BIOGRAPHICAL NOTE
University of Lodz, 10/2017 – 12/2024
• Doctoral Studies: Chemistry
Dissertation title: Synthesis and biological studies of organometallic conjugates of kinesin-5 inhibitors 5
University of Lodz, 10/2015 - 06/2017
• Master’s Degree: Chemistry in Science and Industry
Dissertation title: Synthesis of metallocene analogs of selected anti-mitotic compounds
University of Lodz, 10/2013 - 09/2015
• Bachelor’s Degree: Chemistry in Science and Industry
Dissertation title: Polymerization activators and inhibitors of tubulin
ACHIEVEMENTS
· Karolina Kowalczyk, Andrzej Błauż, Krzysztof Krawczyk, Błażej Rychlik, Damian Plażuk Design and Synthesis of Ferrocenyl 1,4-Dihydropyridines and Their Evaluation as Kinesin-5 Inhibitors,
Dalton Trans., 2024, 53, 16038-16053
· Karolina Kowalczyk, Andrzej Błauż, Daniel Moscoh Ayine -Tora, Christian G. Hartinger, Błażej Rychlik, Damian Plażuk, Design, Synthesis, and Evaluation of Biological Activity of Ferrocene-Ispinesib Hybrids: Impact of a Ferrocenyl Group on the Antiproliferative and Kinesin Spindle Protein Inhibitory Activity, Chem.Eur. J., 2023, 29, e202300813
· Anna Wieczorek-Błauż, Karolina Kowalczyk, Andrzej Błauż, Anna Makal, Sylwia Pawlędzio, Chatchakorn Eurtivong, Homayon J. Arabshahi, Jóhannes Reynisson, Christian G. Hartinger, Błażej Rychlik, Damian Plażuk, Impact of the ferrocenyl group on cytotoxicity and KSP inhibitory activity of ferrocenyl monastrol conjugates Dalton Trans., 2022, 51, 491-508
· K. Kowalczyk, A. Błauż, W. Ciszewski, A. Wieczorek, B. Rychlik, D. Plazuk,. – Colchicine metallocenyl bioconjugates showing high antiproliferative activities against cancer cell lines,
Dalton Trans., 2017, 48, 17041-17052
· D. Plażuk, A. Wieczorek, W. M. Ciszewski, K. Kowalczyk, A. Błauż, S. Pawlędzio, A. Makal, C. Eurtivong, H. J. Arabshahi, J. Reynisson, C. G. Hartinger and B. Rychlik, Synthesis and in vitro Biological Evaluation of Ferrocenyl Side-Chain-Functionalized Paclitaxel Derivatives, ChemMedChem, 2017, 12, 1882–1982